Postdoctoral Researcher in Stromal Senescence Mechanisms in Prostate Cancer

Position Overview

We are offering a full-time postdoctoral research opportunity funded by a long-term NIH R37 grant to investigate the mechanisms and therapeutic targets of stromal senescence in prostate cancer development. This role is based in the laboratory of Dr. Marcus Ruscetti, Ph.D., at the University of Massachusetts Chan Medical School (UMCMS), Worcester, MA.

Research Focus and Goals

• Identify diverse senescent cell populations and immune cell niches encouraging tumor progression through single cell and spatial transcriptomics.
• Assess the role of age-related senescence on prostate cancer initiation and immune system suppression.

This research sits at the crossroads of cancer genetics, tumor immunology, basic science, and clinical translation. The long-term aim is to translate knowledge of senescence biology's impact on tumor-immune interactions into therapeutic strategies against pancreatic and prostate cancers.

Work Environment

The position is housed within the Department of Molecular, Cell and Cancer Biology (MCCB) at UMCMS, which provides access to advanced core facilities, shared equipment, and a vibrant, intellectually stimulating community. The institution includes around 3,000 faculty members with distinguished awardees and membership in prestigious academies, reflecting a top-tier research environment.

Candidate Qualifications

• Ph.D. and/or M.D. completed recently (within 1 year postdoctoral experience).
• At least one first-author publication in a peer-reviewed journal from doctoral or medical research.
• Minimum one year of experience working with mouse models.
• Background in cancer biology.
• Skilled in cell culture and molecular biology techniques.

Preferred Qualifications

• Highly self-driven and motivated.
• Collaborative approach within and outside the research group.
• Strong organizational skills with ability to plan experiments and meet deadlines.
• Ability to independently execute and analyze research experiments.
• Experience with genome editing, histological techniques, microscopy, immunology assays, flow cytometry, and high-throughput sequencing technologies preferred.

Application Instructions

Please submit a cover letter (max one page) outlining your key achievements and relevance to this research, along with your CV, addressed to Dr. Marcus Ruscetti.