PhD in Epithelial Mechanobiology

About the University and Research Group

The University of Marburg, established in 1527, serves roughly 22,000 students and is known for addressing major contemporary challenges through research spanning a wide range of scientific disciplines. The Faculty of Medicine, Institute of Pharmacology, and the research group led by Prof. Dr. Thomas Worzfeld are inviting applications for a PhD position focused on epithelial mechanobiology.

Project Overview

This doctoral project is part of a DFG-funded collaboration within the Transregional Collaborative Research Centre 425, “Desmosomal dysfunction in epithelial barriers” (DEFINE). The work is aimed at uncovering the molecular processes that regulate desmosomes, which are junctional structures that help epithelial tissues maintain mechanical strength. Because desmosome malfunction is closely linked to pemphigus, a serious autoimmune skin disease, the research will also examine whether plexins, a family of transmembrane receptors, could serve as therapeutic targets in this context.

Key Research Methods

The role will involve a broad mix of experimental approaches, including biochemical techniques such as protein crosslinking, affinity purification, and mass spectrometry; cell and molecular biology work with primary keratinocyte cultures and skin organoids; mechanobiology-based assays; advanced imaging; and studies using preclinical mouse models of pemphigus, including FACS and histological analysis.

Responsibilities

• Drive the DFG-supported doctoral project forward with the goal of defining how plexins regulate desmosome function and whether they may be useful targets in pemphigus therapy.
• Assist in preparing research papers, presentations, and other scientific outputs.

Eligibility and Profile

The position is intended for a candidate pursuing a doctoral degree and is fixed-term for three years, in line with German academic fixed-term employment regulations. The start date is as soon as possible. Applicants should hold an M.Sc. degree, or an equivalent qualification, in a life sciences discipline. Strong motivation, creativity, and a collaborative mindset are essential, along with excellent written and spoken English. Prior exposure to biochemical methods, cell and molecular biology, mechanobiology, advanced imaging, animal experimentation, and histology would be an advantage. A readiness to develop an independent scientific profile is expected.

Working Conditions and Benefits

The position is compensated according to the public sector pay scale of the State of Hesse, Germany (TV-H E 13, 65%). In addition to salary and standard benefits, the role offers a dynamic international research setting, a modern campus with strong infrastructure, access to global research networks, structured supervision, and a comprehensive training and mentoring program. Employees also receive free public transportation within Hesse through the state ticket. Junior researchers are further supported through the Marburg Research Academy (MARA), the International Office, and the Higher Education Didactics Office.

Additional Information

The appointment is limited to the period required to complete the doctoral degree.