Doctoral Researcher/PhD in Nucleotide Metabolism in Microbes

About the Position

The University of Marburg, established in 1527 and home to around 22,000 students, offers a stimulating research environment. The Research Training Group “Nucleotide Metabolism in Microbes” (GRK 2937, “MiNu”), funded by the German Research Foundation (DFG), seeks a Doctoral Researcher (PhD) to join a three-year, part-time (65% working hours) project starting October 1, 2026 or later. This role focuses on understanding the chemical building blocks of cellular cofactors and nucleic acids such as DNA and RNA across different microbial species with an aim to elucidate fundamental principles and specific adaptations of nucleotide metabolism and modification.

Project Focus and Responsibilities

The position involves contributing to the subproject “Functional characterization of NUDIX hydrolases and their capped RNA substrates in hyperthermophilic archaea,” led by Prof. Dr. Lennart Randau. The research emphasizes studying the catalytic function, regulation, and structural properties of thermostable enzymes. Key duties include:

• Developing an original, independent research project.
• Studying the catalytic functions and interactions of recombinant proteins with nucleotides.
• Conducting in vivo experiments and genetic manipulation of bacterial (E. coli) and archaeal (S. acidocaldarius) model organisms.
• Characterizing archaeal metabolomes through multidisciplinary collaboration in an international setting.
• Disseminating research findings via publications and conference presentations.
• Assisting in student teaching activities and seminars.

Employment Terms

The position lasts for three years, aligned with the requirements for completing a doctoral degree, and follows regulations under the German Academic Fixed-Term Contract Act. Salary and benefits correspond to the public service level E 13 TV-H of the state of Hesse.

Candidate Profile

• Master’s degree or equivalent in biology, biochemistry, or chemistry, preferably with expertise in biochemistry and microbiology.
• Practical experience in cultivating and genetic studies of archaeal microorganisms.
• Skills in molecular biology techniques (e.g., cloning, hydrolase activity assays) and protein biochemistry (e.g., purification).
• Preferred knowledge of RNA biology in archaea.
• Strong curiosity, high motivation, and enthusiasm for independently developing research projects.
• Team-oriented mindset with a passionate approach to scientific inquiry.

Support and Benefits

• Access to a dynamic research environment with modern infrastructure.
• A public transportation ticket for Hesse state allowing free travel.
• Participation in company pension scheme (VBL).
• Professional development opportunities through the Marburg Research Academy, International Office, and graduate programs.
• Commitment to family-friendly policies and support for work-life balance, including options for reduced working hours.

Equal Opportunity Statement

The university encourages women to apply and prioritizes them in underrepresented fields when qualifications are equal. Applicants with disabilities as defined by German social security codes will also be given preference. Application and interview-related expenses cannot be reimbursed.

Application Details

Applications must be submitted by August 9, 2026. For further information, contact Prof. Dr. Lennart Randau at +49 6421-28 23320 or lennart.randau@staff.uni-marburg.de.