Scientist / Senior Scientist - Protein Science and Structural Biology

About Sygnature Discovery

Sygnature Discovery is a global contract research organization (CRO) with over 700 scientists from more than 50 countries working collaboratively across Europe and North America. The company focuses on supporting customers in developing transformative medicines, providing comprehensive confidentiality and dedication. With over 20 years of experience, Sygnature has contributed to more than 60 advanced drug candidates, filed over 250 patents, and managed 200+ active projects. Their client retention rate exceeds 90%, working with biotech startups and pharmaceutical companies for specialized challenges.

Role Overview

The Protein Science team at Sygnature Discovery specializes in engineering, expressing, and purifying tailored proteins from various classes for applications such as biochemical screening, biophysical characterization, diagnostics, and biologic drug discovery. The team also conducts structural studies using X-ray crystallography, Cryo-EM, and protein NMR, offering opportunities to work alongside experts with state-of-the-art technologies.

Due to expansion, the company seeks Scientists and Senior Scientists to join their Protein Science team at the Tytherington site in Macclesfield. Candidates should be curious and passionate, with practical experience in protein expression, purification, and structural determination. Expertise in protein engineering and biophysical or structural characterization methods is advantageous.

Key Responsibilities

• Expression of recombinant proteins using bacterial, insect, and mammalian systems
• Purification and analysis of diverse targets, including membrane proteins
• Perform structural biology techniques such as X-ray crystallography, biomolecular NMR, and Cryo-EM

Required Skills and Qualifications

• A minimum of a BSc, MSc, or PhD in Biochemistry or a related scientific discipline
• Experience in drug discovery within a CRO environment is beneficial but not mandatory
• Ability to deliver successful projects both independently and through flexible collaboration with team members
• Strong problem-solving capabilities, particularly in protein expression, purification, and structural biology techniques
• Excellent interpersonal and communication skills accompanied by a natural curiosity and enthusiasm for scientific challenges

Employee Benefits

• 25 days of annual leave plus bank holidays
• Private medical insurance coverage
• Life insurance protection
• Access to an employee assistance program
• Enhanced family-friendly policies
• Participation in Sygnature Group pension scheme
• One paid volunteer day annually

Additional Information

This recruitment may close early if a large number of applications are received. Interested candidates should apply promptly to seize this opportunity.